Which three factors influence chemical dependence?

The correct answer focuses on the three key components of chemical dependence — Host, Environment, and Agent — which exemplifies a well-rounded model for understanding substance abuse and dependence.

The "Host" factor refers to the individual characteristics, including genetic predispositions, personal history, and mental health status that can make someone more vulnerable to addiction. The "Environment" encompasses societal influences such as family dynamics, socio-economic status, and cultural factors that contribute to either resilience or risk for substance abuse. Finally, the "Agent" denotes the substance involved, its properties, potency, and the manner in which it is consumed, which can significantly affect the likelihood of dependence. All three factors interact and play a critical role in the development of chemical dependence, emphasizing the complexity of addiction.

The other options, while they present important aspects of understanding dependence, break down the influences into different categories not fully encapsulating the interrelationship of these three factors in a cohesive model.